Survivin as a diagnostic and therapeutic marker for thyroid cancer

Mahmoudian-Sani, MR and Alghasi, A and Saeedi-Boroujeni, A and Jalali, A and Jamshidi, M and Khodadadi, A (2019) Survivin as a diagnostic and therapeutic marker for thyroid cancer. Pathol Res Pract.

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Abstract

Thyroid cancer (TC) is known as the most prevalent form of endocrine malignancy. With regard to high heterogeneity of the nodules, problem of discriminating between benign and malignant ones in terms of pathological characteristics, as well as lack of appropriate molecular markers; significant efforts are being made to identify molecular markers that able to detect tumorous lesions. Survivin, the newest member of the family of proteins inhibiting cell apoptosis, has been recently considered as a novel molecule marker for cancer. Studies on TC have also demonstrated distinctive expression of survivin and its splice variants in cancer cells compared to normal ones. Therefore, detection of survivin expression and its new splice variants can be utilized to identify tumor nodules and distinguish them from non-cancerous ones, along with other routine laboratory methods.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 11 Mar 2019 07:58
Last Modified: 11 Mar 2019 08:01
URI: http://eprints.lums.ac.ir/id/eprint/1597

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