Polyethylenimine: A new differentiation factor to endothelial/cardiac tissue

Hosseinzadeh, Simzar and Nazari, Hojjatollah and Sadegzadeh, Negar and Babaie, Ali and Kabiri, Mahboubeh and Tasharrofi, Noshin and Zomorrod, Mahsa Soufi and Soleimani, Masoud (2019) Polyethylenimine: A new differentiation factor to endothelial/cardiac tissue. JOURNAL OF CELLULAR BIOCHEMISTRY, 120 (2). pp. 1511-1521.

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jc...


Among different tissues, endothelial/cardiac types require specific factors to promote myocardial regeneration after occurred injuries. Herein, cardiac stem cells (CSCs) as the major cell population that involved in cardiovascular repair were selected to study the role of polyethyleneimine (PEI) agent on endothelial differentiation. After preparation of electrospun network of PEI with polyacrylonitrile, the related characterizations were carried out including scanning electron microscope (SEM), field-emission SEM, water contact angle, Fourier transform infraredspectroscopy and mechanical properties. Also, the release kinetic of the corresponding agent was studied up to 7 days. The cell differentiation studies were done in the following with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromideassay, Real-time polymerase chain reaction and immunostaining method. The whole obtained results approved the higher differentiation of CSCs into endothelial/cardiac cells. Finally, it is recommended that the PEI delivering increases the healing potency of CSCs and accordingly the regeneration speed of damaged cardiovascular tissue would be improved.

Item Type: Article
Subjects: Q Science > Q Science (General)
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 11 Mar 2019 06:21
Last Modified: 11 Mar 2019 06:21
URI: http://eprints.lums.ac.ir/id/eprint/1586

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