Mutation and Efflux System are Responsible for Ciprofloxacin Resistance in Klebsiella pneumoniae

Zayyen, K. M and Rastegar-Lari, A and Ghafourian, S and Taherikalani, M and Sadeghifard, N and Jalilian, F. A and Badakhsh, B and Hematian, A and Pakzad, I (2018) Mutation and Efflux System are Responsible for Ciprofloxacin Resistance in Klebsiella pneumoniae. WEST INDIAN MEDICAL JOURNAL, 67 (3). pp. 226-28.

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Official URL: https://www.mona.uwi.edu/fms/wimj/article/2721

Abstract

The main mechanism of quinolone resistance in Klebsiella (K) pneumoniae is caused by mutation ofporin-related proteins and efflux pumps. This study aimed to investigate the prevalence of ciprofloxacin-resistant K pneumoniae in burns patients and to understand the role of the AcrAB multidrug efflux system on minimal inhibitory concentration (MIC) of ciprofloxacin. For this reason, 52 K pneumoniae samples were collected from burns patients and evaluated for the mechanism of ciprofloxacin resistance. The results demonstrated that 40 isolates of K pneumoniae were ciprofloxacin-resistant and 35 showed the mutation on gyrA locus. By inhibition of the efflux system, the MIC yield showed a significant decrease. Therefore, it could be concluded that the high rate of mutation on the gyrA locus in combination with quinolone resistance was responsible for ciprofloxacin resistance and by inhibition of AcrA, the resistance rate showed a significant decrease in K pneumoniae isolated from burns patients.

Item Type: Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 22 Dec 2018 11:37
Last Modified: 22 Dec 2018 11:37
URI: http://eprints.lums.ac.ir/id/eprint/1517

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