APOE Gene Polymorphism in Patients with Alzheimer’s Disease in Iran

Naji, Tahereh and Ebrahimi, Ebrahim and Anari, Marzieh and Mobasheri Demneh, Hojatolla* (2018) APOE Gene Polymorphism in Patients with Alzheimer’s Disease in Iran. Yafteh, 20 (3).

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Abstract

Background: Alzheimer's disease is a multi-factorial disorder. The genes involved in Alzheimer's disease act as risk factors. The aim of this study was to investigate the APOE gene polymorphism in patients with Alzheimer's disease in Iran. Materials and Methods: In this analytical-descriptive study, 50 patients with Alzheimer's were investigated. Polymorphism of the APOE gene was investigated in healthy subjects and patients with Alzheimer's using Tetra Arms PCR. Results: The frequency of the 4ε /4ε genotype and ε4 allele was significantly higher in patients with Alzheimer's compared to healthy subjects (38/4% and57/4% versus 3/8% and 28/8%, respectively) (P≥0.009). Conclusion: In polymorphism of the APOE gene, the 4ε /4ε genotype, and the ε4 allele, are risk factors for Alzheimer's disease in the Iranian population. Keywords: Alzheimer's disease, APOE Gene, Iranian population

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Depositing User: Samira Sepahvandy
Date Deposited: 12 Dec 2018 06:25
Last Modified: 12 Dec 2018 06:25
URI: http://eprints.lums.ac.ir/id/eprint/1504

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