Correlation of Maternal KIR and Parental HLA-C Genes Diversity With Risk of Preeclampsia in Lorestan Province of Iran

Akbari, Soheila and Ahmadi, Seyyed Amir Yasin and Shahsavar, Farhad and Anbari, Khatereh (2018) Correlation of Maternal KIR and Parental HLA-C Genes Diversity With Risk of Preeclampsia in Lorestan Province of Iran. INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES, 6 (4). pp. 452-458.

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Abstract

Objectives: Fetomaternal immune tolerance induced by natural killer cells (NKs) is a necessary phenomenon associated with maternal killer-cell immunoglobulin-like receptors (KIRs) and fetal human leukocyte antigens (HLAs). We aimed to investigate maternal KIR, parental HLA-C, and maternal-parental KIR-HLA combination in 2 preeclampsia and control groups. Materials and Methods: A total of 200 couples participated in this case-control study. DNA samples were assayed through polymerase chain reaction with sequence specific primers (PCR-SSP). Results: No significant difference was observed between the cases and the controls regarding the maternal KIR genes and genotypes and paternal HLA-C genes. A significant relation was found for maternal KIR and paternal HLA-C combination. The relation was for the inhibitory combination KIR2DL1+HLA-C2 in the preeclampsia group (P < 0.05; odds ratio [OR] = 2.02; sensitivity = 79%). In addition, maternal AA genotype of KIR in combination with paternal HLA-C1C2 was a risk factor (P < 00.05; OR = 3.24; specificity = 92%). Conclusions: The inhibitory maternal-paternal combinations KIR2DL1+HLA-C2 and AA+HLA-C1C2 seem to be more associated with risk of preeclampsia. Prediction of the risk of preeclampsia with the help of maternal KIR typing and paternal HLA-C typing can be possible in future.

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