Prevalence of nosocomial infections in Iran: A systematic review and meta-analysis

Ghashghaee, A and Behzadifar, M and Azari, S and Farhadi, Z and Bragazzi, Nicola Luigi and Behzadifar, M and Shahri, Sahar Sadat Saeedi and Ghaemmohamadi, Mozhgan Sadat and Ebadi, F and Mohammadibakhsh, R and Seyedin, H and Moghadam, M.R (2018) Prevalence of nosocomial infections in Iran: A systematic review and meta-analysis. Medical Journal of the Islamic Republic of Iran, 32 (1).

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Abstract

Background: Nosocomial infections represent a serious public health concern worldwide, and, especially, in developing countries where, due to financial constraints, it is difficult to control infections. This study aimed to review and assess the prevalence of nosocomial infections in Iran. Methods: Different databases were searched between January 2000 and December 2017. To determine the pooled prevalence, the stochastic DerSimonian-Laird model was used, computing the effect size with its 95% confidence interval. To examine the heterogeneity among studies, the I2 test were conducted. The reporting of observational studies in epidemiology (STROBE) checklist was used to assess the methodological quality of observational studies. To further investigate the source of heterogeneity, meta-regression analyses stratified by publication year, sample size and duration of hospitalization in the hospital were carried out. Results: 52 studies were included. Based on the random-effects model, the overall prevalence of nosocomial infection in Iran was 4.5% [95% CI: 3.5 to 5.7] with a high, statistically significant heterogeneity (I2=99.82%). A sensitivity analysis was performed to ensure the stability results. After removing each study, results did not change. A cumulative meta-analysis of the included studies was performed based on year of publication and the results did not change. In the present study, a high rate of infections caused by Klebsiella pneumoniae (urinary tract, respiratory tract, and bloodstream infections) was found. Conclusion: Preventing and reducing hospital infections can significantly impact on reducing mortality and health-related costs. Implementing ad hoc programs, such as training healthcare staff on admission to the hospital, may play an important role in reducing infections spreading.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 28 Oct 2018 11:19
Last Modified: 28 Oct 2018 11:19
URI: http://eprints.lums.ac.ir/id/eprint/1440

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