Embryonic Stem Cells and Infertility

Lorzadeh, Nahid and Kazemirad, Nastaran (2018) Embryonic Stem Cells and Infertility. AMERICAN JOURNAL OF PERINATOLOGY, 35 (10). pp. 925-930.

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Embryonic stem cells (ESCs) have the ability to differentiate into several cell lineages and self-renew. Through a spontaneous process, ESCs can differentiate into germ cells of various stages, partly due to their self-renewal ability and their microenvironment culture. Human and mouse ESC differentiation into putative primordial germ cells (PGCs) has been demonstrated by several studies; in fact, derivation of functional mouse male gametes has also been reported. However, the exact underlying mechanisms are yet to be understood properly, and as such clinical applications of ESC-derived PGC remains controversial. Nonetheless, this technique can still serve as a potential treatment option for infertility. This review centers on the available reports on the possible application of ESC for infertility treatment.

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 20 Aug 2018 06:45
Last Modified: 20 Aug 2018 06:45
URI: http://eprints.lums.ac.ir/id/eprint/1342

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