Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma

Ahmadi, Koroosh and Mohammadi, Mohsen and Safaei, Hamid Reza and Rostamzadeh, Ayoob and Ghaderi, Omid and Yahaghi, Hamid (2015) Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma. Tumor Biol..

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Abstract

Abstract In order to evaluate the correlation of B7-H4 and B7-H1 with renal cell carcinoma (RCC), we analyzed B7-H1 and B7-H4 expressions and their clinical significance by immunohistochemical method. Our result indicated that B7-H4- positive staining was detected in 58.13 % of RCC tissues (25 tissues tumors), and there were 18 tissues of patients without detectable B7-H4. Furthermore, 21 cases (48.83 %) were B7- H1-positive. Positive tumor expressions of B7-H4 and B7-H1 were markedly related to advanced TNM stage (P = 0.001; P= 0.014), high grade (P= 0.001; P= 002), and larger tumor size (P= 0.002; P= 024) in RCC tissues than patients with B7- H4-negative and B7-H1-negative in RCC tissues. The patients with B7-H1 and B7-H4-positive expressions were found to be markedly correlated with the overall survival of the patients (P< 0.05) and tended to have an increased risk of death when compared with negative expression groups. Univariate analysis showed that B7-H4 and B7-H1 expressions, TNM stage, high grade, and tumor size were significantly related to the prognosis of RCC. Furthermore, multivariate analysis showed that B7-H4 and B7-H1 expressions decreased overall survival. The adjusted HR for B7-H1 was 2.83 (95 % CI 1.210–2.971; P = 0.031) and also was 2.918 (95 % CI 1.243–3.102; P= 0.006) for B7-H4 that showed these markers were independent prognostic factors in RCC patients. The expressions of B7-H1 and B7-H4 in RCC patients indicate that these markers may be as a predictor of tumor development and death risk. Further investigations can be helpful to confirm B7-H1 and B7-H4 roles as an independent predictor of clinical RCC outcome. Keywords B7-H1 and B7-H4 . Renal cell carcinoma . Analysis . Prognosis . Immunohistochemistry

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