Effect of Low-Dose Naloxone on Pain Severity and Side Effects of Opioids on Patients Undergoing Laparoscopic Cholecystectomy

Toolabi*, Karamollah and Moazamipur, Ali and Karvandian, Kasra and Dehpour, Ahmad Reza (2018) Effect of Low-Dose Naloxone on Pain Severity and Side Effects of Opioids on Patients Undergoing Laparoscopic Cholecystectomy. Yafte, 20 (1).

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Abstract

Background : Previous studies have assessed the effect of naloxone on pain severity and its side effects of opioids however, their results are inconsistent. The study was designed to determine effect of low-dose naloxone on pain, nausea, vomiting, pruritus and urine retention on the patients who are undergoing laparoscopic cholecystectomy. Materials and Methods: In this study 60 patients who needed laparoscopic cholecystectomy participated and were divided into two groups: naloxone (0.25 mg/kg/h naloxone plus 20 mg/kg/h morphine) and placebo (20 mg/kg/h morphine). Patients were evaluated 2, 4, 8, and 16 hours after surgery and the severity of pain and its side effects including nausea, vomiting, pruritus and urine retention were recorded by a nurse. Results: Prevalence of nausea, vomiting, pruritus and urine retention in naloxone group was significantly lower than placebo 2, 4, 8, and 16 hours after surgery. There was no significant difference on pain severity between the two groups. Conclusion: Our results indicated that naloxone administration significantly decreased the side effects of opioid including nausea, vomiting, pruritus and urine retention with no effect on pain severity. Keywords: Naloxone, Morphine, Laparoscopic cholecystectomy, Pain, Vomiting.

Item Type: Article
Subjects: R Medicine > RD Surgery
Depositing User: Samira Sepahvandy
Date Deposited: 11 Jun 2018 08:58
Last Modified: 11 Jun 2018 08:58
URI: http://eprints.lums.ac.ir/id/eprint/1320

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