Apigenin improves myocardial function and attenuates cardiotoxicity induced by doxorubicin in male rats

Fallah rajabpour zare, Masoud and Rakhshan, Kamran and Aboutaleb, Nahid and Nikbakht,, Farnaz and Bakhshesh, Morteza and Azizi*, Yaser (2018) Apigenin improves myocardial function and attenuates cardiotoxicity induced by doxorubicin in male rats. Yafte, 20 (1).

[img]
Preview
Text
9.pdf.pdf

Download (441kB) | Preview

Abstract

Background: Doxorubicin has been used in the treatment of malignancies, including lymphoma, leukemia and breast cancer. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin, as a flavonoid, has antioxidant, anti-inflammatory and anti tumoral properties. The aim of this study is the assessment of the effect of apigenin on cardiotoxicity induced by doxorubicin. Materials and Methods: 60 male wistar rats were divided into 6 groups. Cardiotoxicity was induced by 6 injections of doxorubicin (2 mg/kg, ip) over 12 days. The treatment groups received orally 25, 50 and 75 mg/kg/day apigenin for 12 days simultaneously with cardiotoxicity induction. Results: The heart weight to body weight ratio showed no significant difference between different groups. In the apigenin group (25 mg/kg), EF and FS showed a significant increase (P<0.05) and LVEDs, LDH and CK-MB showed a significant decrease, in comparison to the cardiotoxicity group. Conclusion: Apigenin prevents LDH and CK-MB elevation and also EF and FS reduction and improves cardiac tissue changes and leads to a decrease in cardiac damage induced by doxorubicin. Keywords: Apigenin, Doxorubicin, Cardiotoxicity, Echocardiography, Cardiac enzymes.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RZ Other systems of medicine
Depositing User: Samira Sepahvandy
Date Deposited: 11 Jun 2018 05:54
Last Modified: 11 Jun 2018 05:54
URI: http://eprints.lums.ac.ir/id/eprint/1317

Actions (login required)

View Item View Item