Metformin; a mini-review to its antioxidative and anti-inflammatory properties

Abbaszadeh, Abolfazl and Koushki, Sahar and Koushki, Shirin and Eskandarzadeh, Marzieh and Hasanvand, Amin (2018) Metformin; a mini-review to its antioxidative and anti-inflammatory properties. Journal of Renal Injury Prevention, 7 (1). pp. 7-10.

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Abstract

Metformin, a hypoglycemic drug, increases peripheral glucose uptake, decreases liver glucose production and suppresses insulin resistance in liver and skeletal muscle. The molecular anti-inflammatory mechanism of metformin involves the reduction of the level of proinflammatory cytokines through AMPK activation. It can reduce endothelial dysfunction by ameliorating the expression of inflammatory gene and protein like vascular cell adhesion molecule-1 (VCAM-1), and vasodilating maternal vessels. Many studies showed that AMPK activation were the main contributors to the antioxidant and anti-inflammatory effects of metformin.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 29 May 2018 06:40
Last Modified: 29 May 2018 06:40
URI: http://eprints.lums.ac.ir/id/eprint/1309

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