Embryonic Stem Cells and Infertility.

Lorzadeh, N and Kazemirad, N (2018) Embryonic Stem Cells and Infertility. Am J Perinatol.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/29490398

Abstract

Embryonic stem cells (ESCs) have the ability to differentiate into several cell lineages and self-renew. Through a spontaneous process, ESCs can differentiate into germ cells of various stages, partly due to their self-renewal ability and their microenvironment culture. Human and mouse ESC differentiation into putative primordial germ cells (PGCs) has been demonstrated by several studies; in fact, derivation of functional mouse male gametes has also been reported. However, the exact underlying mechanisms are yet to be understood properly, and as such clinical applications of ESC-derived PGC remains controversial. Nonetheless, this technique can still serve as a potential treatment option for infertility. This review centers on the available reports on the possible application of ESC for infertility treatment.

Item Type: Article
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 11 Apr 2018 20:29
Last Modified: 11 Apr 2018 20:29
URI: http://eprints.lums.ac.ir/id/eprint/1220

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