The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart

Moghaddasi, Mehrnoush and Taati, Majid and Noroozi, Hasan and Bamani Lirgeshasi, Sam and Pourkhodadad, Soheila and Delfan, Bahram and Nazari, Afshin (2017) The Effects of Olive Leaf Extract Administration on the Cerebral Hypoperfusion-Induced Electrophysiological Alterations in Rat Heart. Herbal Medicines Journal, 2 (3). pp. 105-113. ISSN 2538-2144 (Online)

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Abstract

Abstract Background and Aim: In the present study, the role of ethanolic extract of olive (Olea europaea) leaf administration against the cerebral hypoperfusion-induced electrophysiological alterations and left ventricular thickness in rat heart was studied. Materials and Methods: The right carotid artery was occluded with a 5-0 silk suture and the left carotid artery was occluded after a week. The olive (Olea europaea) leaf extract was administered orally (by gavage) to three experimental groups of rats in 100, 200 and 300 mg/kg/day for two weeks after the left carotid artery occlusion and processed in 25 days. The sham and hypoperfusion groups were fed with normal saline. Each group had 6 rats. After 25 days, electrophysiological heart parameters, i.e. HR, QTc, QRS duration, QT interval, PR interval, RR interval, ST amplitude, T wave amplitude and also the thickness of left ventricle (TLV) were assessed. Results: The administration of olive leaf extract (100, 200 and 300 mg/kg) exhibited its cardioprotective effect by both stabilizing heart rate and preventing ECG changes (such as shortening of PR, QRS, QT and QTc intervals, prominent T waves and ST elevation). Moreover, olive leaf extract (100, 200 and 300 mg/kg) prevented cardiac hypertrophy after cerebral hypoperfusion. Conclusion: Our results indicated that post-treatment with ethanolic extract of olive leaves could prove beneficial effects in managing the cerebral hypoperfusion-induced cardiac abnormality in rats. Keywords: Electrocardiogram, Cerebral hypoperfusion, Left ventricle, Olive leaf extract

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 07 Apr 2018 14:11
Last Modified: 07 Apr 2018 14:11
URI: http://eprints.lums.ac.ir/id/eprint/1196

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