Study of rs1050450, rs4673 and rs13306294 polymorphic distributions and Glutathione Peroxidase-1 (Gpx-1) activity of patients with coronary artery stenosis in Tehran

Mohammadi, Asghar and Hosseini-Fard*, Reza and Ghasemi, Hasan and Alipour, Behnam and Yarnazari, Amene and Hasanpour, Parisa and Roustazadeh, Abazar and Najafi, Mohammad and Shams Beiranvand, Azim and Amirfarhangi, Abdolah (2018) Study of rs1050450, rs4673 and rs13306294 polymorphic distributions and Glutathione Peroxidase-1 (Gpx-1) activity of patients with coronary artery stenosis in Tehran. Yafte, 19 (5).

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Abstract

Background: Coronary artery stenosis is one of the atherosclerotic complications which can lead to decreased oxygen supply in heart tissue and heart attack. rs1050450 Polymorphism is one of polymorphisms in GPx1 gene that may change its antioxidant activity. Furthermore, two polymorphisms of NADPH Oxidase, rs4673 and rs13306294, are suggested to have a role in the function of this enzyme. In this study, we examined the rs1050450, rs4673 and rs13306294 polymorphisms in the patients with coronary artery stenosis. Materials and Methods: 190 angiography subjects are subdivided into two groups (patients (n =114) and control (n =76)). Lipid profile and polymorphic sites were measured by routine laboratory tests and RFLP-(ARMS) PCR, respectively. Results: In this study we, observed the significant difference between serum LDL level and degree of stenosis. Also, we observed significant difference for rs13306294 polymorphism between patients and controls. On the controlling age, gender and BMI, no correlations were observed between rs13306294, rs1050450 and rs4673 polymorphisms and coronary artery stenosis (P<0.05). Conclusion: rs13306294, rs4673 and rs13306294 polymorphisms have not a basic role in the progression of coronary artery stenosis. Keywords: Stenosis, Polymorphism, Rs4673, Rs1050450, Rs13306294.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Samira Sepahvandy
Date Deposited: 27 Feb 2018 07:18
Last Modified: 27 Feb 2018 07:34
URI: http://eprints.lums.ac.ir/id/eprint/1191

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