The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder

Masoumi-Ardakani, Yaser and Mahmoudvand, Hossein and Mirzaei, Amin and Esmaeilpour, Khadijeh and Ghazvini, Hamed and Khalifeh, Solmaz and Sepehri, Gholamreza (2017) The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder. Biomedicine & Pharmacotherapy, 87. pp. 489-495.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28073098

Abstract

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition which develops in 6-8% of the general population. Current standard pharmacological treatments for PTSD cannot be widely used due to having various side effects. Nowadays, various pharmacological properties have been related to Elettaria cardamomum L. (family of Zingiberaceae). The present study aims to evaluate the efficacy of E. cardamomum methanolic extract on anxiety-like behavior in a rat model of PTSD. Adult male Wistar rats (200-250gr) were used in this study. The rats underwent single prolonged stress (SPS) or control and intraperitoneally received either saline or different dosages (200, 400, and 800mg/kg) of E. cardamomum methanolic extract before and after stress sessions. Moreover, open field, elevated plus-maze, and rotarod tests were used to evaluate locomotion and anxiety-like behavior in the rats. Findings demonstrated that E. Cardamomum methanolic extract, particularly at the dose of 400mg/kg, significantly (P<0.05) improved anxiety-like behavior in a rat model of PTSD, as examined by the open field, elevated plus-maze, and rotarod tests. Administration of E. cardamomum methanolic extract after stress might help to prevent the formation of anxiety-like behavior in the animals. However, further studies are requiredto clarify the exact mechanisms involved.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 30 Dec 2017 19:21
Last Modified: 30 Dec 2017 19:21
URI: http://eprints.lums.ac.ir/id/eprint/1133

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